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Medicines that inhibit CYP2D6 action, including paroxetine and quinidine, might induce lessened clearance of oxycodone which could lead to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.These strengths might result in overdose (even Demise)

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